New research indicates that patients who stop using new weight-loss injections like Wegovy and Mounjaro may regain shed pounds at a significantly accelerated pace than those who halt traditional lifestyle plans.
Findings released in a prominent health publication demonstrates that while overweight individuals often shed substantial amounts of their total mass while using the jabs, the weight is regained at an estimated rate of 0.8 kg per month after stopping.
"People using such drugs should be informed of the risk of fast rebound weight gain when the medication is stopped," stated expert Dr. Susan Jebb.
Such speed of recovery suggests a reversion to starting weight in about a year and a half.
Analyzing Therapies
The study, which reviewed dozens of studies involving thousands of patients, contrasted the results of these new drugs with conventional dieting.
Scientists emphasize that individuals who shed pounds through diet and exercise typically see a less rapid weight regain—perhaps 100 grams monthly—after stopping.
Understanding the Quick Regain
Doctors believe the way of the drugs accounts for the accelerated rebound.
GLP-1 drugs imitate a natural hormone called GLP-1, which controls appetite.
"Long-term administration of GLP-1 levels several times higher than the body's typical production might result in the system to produce less of its endogenous GLP-1, and may also lessen responsiveness to its effects," said Dr. Adam Collins, a dietetics expert.
"Discontinuation of this hormone supplement results in hunger is no longer kept in check, making binge eating much more probable."
An Ongoing Disease?
Health authorities suggest the injections for individuals with weight-linked medical conditions, alongside recommended lifestyle changes.
Professionals argue that, given the significant potential of relapse, the treatment is often life-long.
This perspective is echoed by pharmaceutical companies, who note that the results "highlight the long-term character of excess weight," comparing it to managing diseases like high blood pressure.
Patient Accounts
Individuals who have discontinued the medication report a powerful resurgence of hunger.
"It felt as if something activating and I was suddenly starving," said one woman.
The struggle is compounded if individuals have not established lasting lifestyle or habit changes during treatment.
Significant Interest
Survey data indicate that millions of people in the UK have tried weight-loss jabs in the last 12 months, with demand continuing to grow.
- Use is higher among females compared to men.
- The middle-aged age group shows the greatest usage rates.
- Many obtain the medications through private prescriptions rather than the NHS.
Ultimately, researchers emphasize that while these medications are potent tools for weight loss, they are not a permanent fix and maintained weight loss likely depends on combined lifestyle management.
